Register to ASCB|EMBO 2019 TechTalk

The Missing Link in Cell Culture: In Vitro Vascularization of Human Organoids and Tissue Explants

10:45-11:45 am
Theater 2, Exhibit Hall
Presenters: Jos Joore, Dorota Kurek, and Marianna Kruithof-de Julio
Level: Intermediate

The OrganoPlate® Graft is the first microfluidic cell culture platform that allows you to study the vascularisation of 3D tissues in vitro. While functional blood vessels are vital for the functioning of organs and the body as a whole, they are lacking in all the currently available in vitro cell culture techniques. The OrganoPlate Graft is a newly developed version of the OrganoPlate based on the unique technology developed by MIMETAS. It is designed to grow functional microvessels in a chip to create a microvascular bed. Tissue placed onto this bed can be connected to the system of human blood vessels, allowing in vitro vascularization.

In this session we will introduce the platform and its applications. Following this introduction Dr. Marianna Kruithof-de Julio will present the work that she has performed with the OrganoPlate Graft. Her presentation will focus on overcoming the issues of tumor heterogeneity in drug research by creating a complex model to study drug treatment effectiveness by combining organoid technology with the OrganoPlate Graft. With this approach they aim to better mimic the in vivo systemic administration of compounds and to study the contribution of the vascular network in therapy response.